Why Do We Do pH in the Pharmaceutical Industry?

pH is a measure of a solution's acidity or alkalinity. In the pharmaceutical industry, pH is important because it can affect the stability, efficacy, solubility, and bioavailability of drugs:

pH is mesured in the pharmaceutical industry to check/ensure:

1. Drug stability

The stability of many drugs is affected by pH.  For example, some drugs may degrade or lose potency when exposed to acidic or alkaline environments.  Therefore, controlling pH is important to ensure the stability of drugs and prevent the degradation of active pharmaceutical ingredients.

2. Solubility

The solubility of many drugs is also influenced by pH. Some drugs may have limited solubility in acidic or alkaline solutions, which can affect their bioavailability and therapeutic efficacy. By adjusting the pH of a drug solution, it may be possible to improve its solubility and enhance its effectiveness.

3. Delivery system

pH is also an important consideration when designing drug delivery systems, such as sustained-release tablets or capsules. The pH of the environment in which the drug is released can affect the rate and extent of drug release.

4. Drug interactions

The pH of bodily fluids, such as blood and urine, can affect the absorption, distribution, and elimination of drugs. Therefore, understanding the pH of the body and the drugs being administered is important to ensure optimal therapeutic outcomes.

Overall, pH is an essential parameter in the development, manufacture, and administration of pharmaceuticals, and careful monitoring and control of pH is critical to ensure drug efficacy, stability, and safety.

pH is measured to:

  • Test for quality
  • Control microbial activity
  • Control taste and other properties
  • Prolong shelf life
  • Check for impurities or infection in milk

The pH scale ranges from 0 to 14, with 7 being neutral. Acids Have a pH less than 7. Acids have more H+ ions, which makes them more acidic. Acids are usually corrosive and turn blue litmus red. Examples of acids include: HCl. Where Bases Have a pH greater than 7. 

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Resource Person: Mohamed Ezz

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